High-Quality Folic Acid Vitamin B9 Food Grade - Pure Folic Acid for Health Products
Introduction to Folic Acid Science
Folic acid (pteroylmonoglutamic acid) represents the most stable and bioavailable form of folate for nutritional fortification. Our food-grade folic acid meets stringent pharmacopeial standards, offering manufacturers a bright yellow crystalline powder with exceptional purity and consistent performance. As a critical methyl donor and nucleotide synthesis cofactor, this essential B vitamin plays fundamental roles in cell division, neural development, and epigenetic regulation, making it indispensable for prenatal health, cardiovascular protection, and comprehensive wellness formulations.
Key Product Specifications
Chemical Name: Pteroyl-L-glutamic acid
Molecular Formula: C₁₉H₁₉N₇O₆
Purity: ≥97% (USP/FCC/EP standards)
Appearance: Yellow to orange-yellow crystalline powder
Solubility: 0.0016g/L in water (improves with pH adjustment)
Thermal Stability: Stable up to 100°C (212°F)
Certifications: FCC, USP, EP, FDA 21CFR172.345 GRAS
Biochemical Functions & Clinical Significance
1. Cellular Proliferation Support
DNA/RNA synthesis cofactor
Thymidylate production
Purine biosynthesis
Rapidly dividing cell support
2. Methylation Cycle Regulation
Homocysteine conversion to methionine
Epigenetic DNA methylation
Neurotransmitter synthesis
Histone modification
3. Developmental Applications
Neural tube closure (400-800μg/day)
Fetal organogenesis
Placental development
Childhood growth
4. Specialized Health Benefits
Cardiovascular protection
Cognitive function maintenance
Mood regulation
Chemotherapy adjunct
Target Populations for Supplementation
Preconception/Pregnancy: 400-800μg daily
MTHFR Polymorphism: Impaired conversion
Elderly: Absorption decline
Cardiovascular Patients: Homocysteine control
Alcohol-dependent: Increased excretion
Supplement & Fortification Applications
1. Nutritional Supplements
Prenatal formulations (400-1000μg)
B-complex products
Cardiovascular health blends
Senior multivitamins
2. Food Fortification
Enriched flour (140μg/100g)
Breakfast cereals
Infant formulas
Meal replacement products
3. Clinical Nutrition
Therapeutic repletion protocols
Oncology support
Malabsorption syndromes
Hematologic disorders
Technical Advantages for Manufacturers
1. Enhanced Stability Profile
Superior to reduced folate forms
Maintains potency in multivitamin blends
Withstands standard food processing
2. Bioavailability Optimization
Efficient dihydrofolate reductase conversion
Standardized absorption kinetics
Predictable serum response
3. Formulation Versatility
Microencapsulation options
Compatible with direct compression
Stable in pH 4-8 systems
Quality & Safety Assurance
Global Regulatory Status
FDA: GRAS (21CFR172.345)
EU: Approved food additive
WHO: Mandatory fortification guidelines
Codex: Included in NRVs
Safety Considerations
UL established at 1000μg (synthetic)
Masking B12 deficiency risk
Drug interaction monitoring
Quality Control Protocol
HPLC purity verification
Heavy metals
Residual solvent analysis
Microbiological standards compliance
Usage Guidelines
Recommended Daily Intakes
Adults: 400μg DFE
Pregnancy: 600μg DFE
Lactation: 500μg DFE
Therapeutic doses: 1-5mg
Formulation Best Practices
Dry Blending: Uniform distribution
Liquid Systems: Solubilizer required
Protection: From light and moisture
Stability Considerations
Amber glass/opaque packaging
Storage below 25°C (77°F)
Avoid reducing agents
Why Choose Our Folic Acid?
1. Scientific Validation
Batch-specific certification
Photostability studies
Bioequivalence data
2. Technical Support
Stability testing protocols
Bioavailability enhancement
Regulatory documentation
3. Supply Chain Excellence
cGMP manufacturing
Light-protected packaging
Global distribution network
Market Trends & Innovations
Prenatal Nutrition: Neural protection
Precision Nutrition: MTHFR targeting
Healthy Aging: Methylation support
Clean Label: Fermentation-derived options
Sustainability Features
Eco-friendly synthesis
Reduced packaging waste
Energy-efficient production
SA | 213.28 |
XLogP3 | -1.1 |
Appearance | Folic acid appears as odorless orange-yellow needles or platelets. Darkens and chars from approximately 482°F. |
Density | 1.68 g/cm3 |
Melting Point | 250 °C (decomp) |
Refractive Index | 1.755 |
Water Solubility | H2O: 1.6 mg/L (25 ºC) |
Storage Conditions | 2-8ºC |
Vapor Pressure | 6.2X10-20 mm Hg at 25 deg C /Estimated/ |
Specific rotation | Specific optical rotation: +23 deg at 25 °C/D (c= 0.5 in 0.1 N sodium hyroxide) |
Odor | Odorless or almost odorless |
Taste | Tasteless |
PH | A suspension of 1 g of folic acid in 10 ml of water has a pH of 4.0-4.8. Aq solutions prepared with sodium bicarbonate have a pH between 6.5 and 6.8. |
Use:
Medication. Biochemical research; clinical drugs are vitamin B family, used for the treatment of pregnancy and infantile giant cell anemia. Anti-anemia drugs for symptomatic or nutritional giant cell anemia. Used as a biochemical reagent, also used in the pharmaceutical industry and other purposes. Folic acid is an anti-anemia drug. When livestock and poultry lack folic acid, appetite decreases, growth is blocked, and feathers grow poorly. The dosage is 0.5-1.0mg/kg. As a food fortifier. It can be used in foods for infants and young children with a dosage of 380-700üg/mg; in special foods for pregnant women and nursing mothers, the dosage is 2 to 4mg/kg. Anti-anemia drugs; can also prevent most neural tube defects (NTDs).



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